研究方向：母胎免疫稳态
擅长领域：基于固有免疫细胞探索母胎对话机制及靶向干预流产的诊疗策略研究。
学术成果：
一、主持或参加科研项目(课题)及人才计划项目情况(按时间倒序排序)：
1、广东省自然科学基金-面上项目(2022A1515010850)：滋养细胞来源外泌体miR-410-5p调控BCL-G抑制蜕膜基质细胞凋亡的机制研究.(2022.01.01-2024.12.31)在研，参与
2、[4] 深圳市自然科学基金-面上项目(JCYJ20210324123601004)：卵巢子宫内膜异位症卵泡液巨噬细胞极化参与调控卵子质量的机制研究.(2021.10.28-2024.10.31)在研，参与
3、[3] 深圳市自然科学基金-面上项目(JCYJ20190813161010761)：滋养层细胞与母胎界面巨噬细胞极化的相互作用及机制研究.(2020.08.10-2023.08.31)在研，参与
4、广东省自然科学基金-面上项目(2019A1515011315)：IGF-1通过上调子宫基质细胞丙酮酸激酶的表达促进蜕膜化的机制研究.(2019.10.01-2022.09.30))结题，参与
二、代表性研究成果和学术奖励(分类按时间倒序排序)：
论文
1. Jing Yang#, Linlin Wang#, Jingwen Ma#, Lianghui Diao, Jiao Chen, Yanxiang Cheng*, Jing Yang*, Longfei Li*. Endometrial proteomic profile of patients with repeated implantation failure. Frontiers in Endocrinology. DOI 10.3389/fendo.2023.1144393.
2. 王琳琳，沈燕琼，杨静，武娅娅，李龙飞*，程艳香. 胰岛素样生长因子1在母-胎界面生物学功能和调节机制进展. 中华生殖与避孕杂志，2023年10月第43卷第10期. DOI: 10.3760/cma.j.cn101441-20220707-00288.
3. 王琳琳，邓志敏，周林燕，杨静，赵玉林，李龙飞*，程艳香*. 多组学技术探讨GRAP2在复发性流产中的潜在作用机制. 生殖医学杂志2022年12月第31卷第12期. DOI:10.3969/j.issn.1004-3845.2022.12.017.
4. Linlin Wang#, Zhimin Deng#, Jing Yang, Yulin Zhao, Linyan Zhou, Lianghui Diao, Longfei Li*, Yanxiang Cheng*. Epigenetic and transcriptomic characterization of maternal-fetal interface in patients with recurrent miscarriage via an integrated multi-omics approach. Journal of Reproductive Immunology. 2022, 154: 103754.
5. Jianan Li#, Linlin Wang#, Jinli Ding#, Yanxiang Cheng, Lianghui Diao, Longfei Li*, Yan Zhang* and Tailang Yin*. Multiomics Studies Investigating Recurrent Pregnancy Loss: An Effective Tool for Mechanism Exploration. Frontiers in immunology. 2022, 13:826198.
6. Linyan Zhou#, Linlin Wang#, Qiang Geng#, Hongzhan Zhang, Shiru Xu, Lianghui Diao, Yong Zeng, Meilan Mo*, Longfei Li*. Endometriosis is associated with a lowered cumulative live birth rate: A retrospective matched cohort study including 3071 in vitro fertilization cycles. Journal of Reproductive Immunology. 2022, 26(151):103631.
7. Linlin Wang#, Longfei Li#*, Yuye Li, Chunyu Huang, Ruochun Lian, Tonghua Wu, Jingwen Ma, Yan Zhang, Yanxiang Cheng, Lianghui Diao* and Yong Zeng*. A history of endometriosis Is associated with decreased peripheral NK cytotoxicity and increased infiltration of uterine CD68+ macrophages. Frontiers in immunology. 2021, 12:711231.
8. Linlin Wang#, Longfei Li#, Chunyu Huang, Lianghui Diao, Ruochun Lian, Yuye Li, Shan Xiao, Xiuyu Hu, Meilan Mo* and Yong Zeng*. Maternal chronic hepatitis B virus infection does not affect pregnancy outcomes in infertile patients receiving first in vitro fertilization treatment. Fertility and sterility. 2019, 112(2):250-257.
9. Longfei Li#, Linlin Wang#, Chunyu Huang, Lianghui Diao, Yongnu Zhang, Xu Zhang, Jian Xu and Yong Zeng*. Chronic hepatitis B infection alters peripheral immune response in women with reproductive failure. American Journal of Reproductive Immunology. 2019, 81(3): e13083.
专利
1. 叶锦韶，王琳琳. 一种双层电泳胶染色装置和自动化电泳胶染色装置(ZL 2018 2 1131681.5)
奖励
湖北省科技进步奖-二等奖，反复妊娠失败的诊疗策略和技术创新(2023)，本人排名第八