助理研究员、深圳中山妇产医院临床研究中心科研主管、主要研究方向为子宫内膜炎对不孕症的影响,子宫内膜T细胞在胚胎着床过程中的功能研究及T细胞分型在临床诊断中的应用;任职广东省免疫学会会员。
擅长领域: 子宫内膜炎对不孕症的影响,子宫内膜T细胞在胚胎着床过程中的功能研究及T细胞分型在临床诊断中的应用
学术任职:广东省免疫学会会员
学术成果:
一、主持或参加科研项目(课题)及人才计划项目情况(按时间倒序排序):
1、深圳市自然科学基金,慢性子宫内膜炎抑制SPHK1/S1P介导的信号通路引起内膜蜕膜化障碍的机制研究,2022-2026,主持,在研。
2、深圳市自然科学基金,早孕期滋养细胞通过IDO-AhR诱导蜕膜CD8+T细胞PD-1表达的机制研究,2020-2023,参与,结题。
3、深圳市科创委基础研究项目,反复种植失败患者子宫内膜CD8+T细胞PD-1的表达及分子调控机制的研究,2019-2022,主持,结题。
4、国家自然科学基金,HIF-1α与雌激素协同调控Tregs功能和子宫内膜微环境的机制研究,2017-2020,参与,结题。
5、广东省科技厅项目,子宫驻留调节性T细胞参与调控免疫微环境和胚胎种植的机制研究,2017-2020,参与,结题。
6、中华医学会临床医学科研专项基金,子宫内膜CD8+T细胞对滋养层细胞调控机制的研究,2017-2019,参与,结题。
二、代表性研究成果和学术奖励(分类按时间倒序排序):
1)Shuyi Yu#, Lianghui Diao , Ruochun Lian , Cong Chen , Chunyu Huang, Xinyuan Li, Yuye Li*and Yong Zeng* . Comparing the peri-implantation endometrial T-bet/GATA3 ratio between control fertile women and patients with recurrent miscarriage: establishment and application of a reference range. Hum Reprod. 2023 Sep 5;38(9):1680-1689.
2) Shuyi Yu#, Chunyu Huang, Ruochun Lian, Lianghui Diao, Xueling Zhang, Songchen Cai, Hongxia Wei, Cong Chen, Yuye Li*, Yong Zeng*. Establishment of reference intervals of endometrial immune cells during the mid-luteal phase. J Reprod Immunol. 2023 Mar;156:103822.
3)Yuye Li#, Shuyi Yu#, Chunyu Huang, Ruochun Lian, Cong Chen, Su Liu, Longfei Li, Lianghui Diao, Udo R. Markert, and Yong Zeng*. Evaluation of Peripheral and Uterine Immune Status of Chronic Endometritis in Recurrent Reproductive Failure Patients, Fertility and Sterility, 2020 Jan;113(1):187-196.
4) Yuye Li#, Shuyi Yu#, Chunyu Huang, Lianghui Diao, Cong Chen, Wenjuan Liu, Ruochun Lian, Meilan Mo, Chenyang Du, Fenghua Liu, Yong Zeng*. Predictive role of endometrial T-bet/GATA3 ratio during mid-luteal phase for live birth in patients undergoing in vitro fertilization: A retrospective observational study. J Reprod Immunol. 2022 Feb;149:103465.
5) ShuYi Yu#, RuoChun Lian, Cong Chen, Xian Chen, Jian Xu, Yong Zeng* and YuYe Li* .Impact of body mass index on peripheral and uterine immune status in the window of implantation in patients with recurrent reproductive failure. Hum Fertil (Camb). 2023 Dec;26(5):1322-1333.
6)Yuye Li#, Shiru Xu, Shuyi Yu, Chunyu Huang, Shenglai Lin, Wanru Chen, Meilan Mo, Ruochun Lian, Lianghui Diao, Lijun Ding*, Yong Zeng*. Diagnosis of chronic endometritis: How many CD138+ cells/HPF in endometrial stroma affect pregnancy outcome of infertile women? Am J Reprod Immunol. 2020 Nov 5:e13369. doi: 10.1111/aji.13369.
7) Yuye Li#, Yanhong Xu#, Shuyi Yu, Shenglai Lin, Wanru Chen, Ruochun Lian, Lianghui Diao, Haixiang Sun, Lijun Ding, Yong Zeng*. Chronic Endometritis Impairs Embryo Implantation in Patients with Repeated Implantation Failure: A Retrospective Study. Taiwanese Journal of Obstetrics and Gynecology. 2022 Nov;61(6):984-988.
8)余姝毅#,连若纯,曾勇,李玉叶*,蜕膜CD8+T细胞在妊娠免疫调节中的作用,生殖医学杂志,2019,28(4)440-443.
9)李玉叶; 余姝毅; 黄春宇; 连若纯; 刁梁辉; 杜晨阳; 陈聪; 黎心缘; 曾勇 ; 一种用于预测不孕症患者的妊娠结局的生物标志物及其应用, 2022-7-12, 中国, ZL202010744091.5
10)张雁、赵龙、余姝毅、郑骏恒,一种脱细胞舌基质材料及其制备方法,2016.10.05,中国,ZL2014106649735